| Autor: |
Chesley A. Kemp, Donna K. McCullough, Dobrusia Bialonska, Paul J. T. Johnson |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Microbiology Research, Vol 12, Iss 2, Pp 376-382 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2036-7481 |
| DOI: |
10.3390/microbiolres12020025 |
| Popis: |
Quorum sensing (QS) is a form of bacterial communication involved in the production of virulence factors in many species. As a result, inhibition of quorum sensing may be of use in mitigating pathogenesis. The signaling molecule indole is currently being investigated as a target for quorum sensing inhibition (QSI) and the indole derivative indole-3-carboxaldehyde (ICA) has been shown to inhibit quorum sensing-mediated behaviors in Escherichia coli. In this study, we investigate bromination as a method of increasing the QSI capabilities of indole carboxaldehydes. The IC50 values of three monobrominated indole carboxaldehydes (5-bromoindole-3-carboxaldehyde, 6-bromoindole-3-carboxaldehyde, and 7-bromoindole-3-carboxaldehyde) were determined and compared to the IC50 value of ICA. The bromination of these indole carboxaldehydes reduced the IC50 values between 2- and 13-fold, indicating that bromination significantly increases the potency of these indole carboxaldehydes. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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