A cohort study comparing the effects of medical cannabis for anxiety patients with and without comorbid sleep disturbance

Autor: Matthew Murphy, Simon Erridge, Carl Holvey, Ross Coomber, James J. Rucker, Mikael H. Sodergren
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Neuropsychopharmacology Reports, Vol 44, Iss 1, Pp 129-142 (2024)
Druh dokumentu: article
ISSN: 2574-173X
DOI: 10.1002/npr2.12407
Popis: Abstract Background Research on cannabis‐based medicinal products (CBMPs) in anxiety remains inconclusive due to a paucity of high‐quality evidence. Studies indicate a bidirectional relationship between generalized anxiety disorder (GAD) and sleep disruption, but it is unclear how this affects CBMP treatment outcomes. This study aims to compare the patient‐reported outcome measures (PROMs) of patients prescribed CBMPs for GAD, with and without impaired sleep. Methods Changes in PROMs were recorded from baseline to 1, 3, 6, and 12 months between those with impaired or unimpaired sleep. Multivariate logistic regression was applied to compare factors associated with a clinically significant improvement in GAD‐7 at 12 months. Secondary outcomes included adverse event incidence and frequency. Results Of the 302 patients that fit the inclusion criteria, mean GAD‐7, single‐item sleep quality, and EQ‐5D‐5L index values improved at all time points (p
Databáze: Directory of Open Access Journals
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