Upregulation of long non‐coding RNA myocardial infarction‐associated transcription is correlated with coronary artery stenosis and elevated inflammation in patients with coronary atherosclerotic heart disease

Autor: Zhi‐Sheng Yan, Nian‐Cai Zhang, Kun Li, Hai‐Xia Sun, Xiao‐Mei Dai, Gao‐Li Liu
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Kaohsiung Journal of Medical Sciences, Vol 37, Iss 12, Pp 1038-1047 (2021)
Druh dokumentu: article
ISSN: 2410-8650
1607-551X
DOI: 10.1002/kjm2.12444
Popis: Abstract Coronary atherosclerotic heart disease (CAD) is a chronic disease caused by multiple risk factors. Aberrant expression of long non‐coding RNAs (lncRNAs) has been regarded as an independent risk factor of CAD. This study evaluated lncRNA myocardial infarction‐associated transcription (MIAT) expression in CAD patients and its clinical significance. Totally, 155 CAD patients and 76 non‐CAD controls were enrolled. MIAT expression was detected using reverse transcription quantitative polymerase chain reaction. The clinical diagnostic significance of MIAT was evaluated by plotting the receiver operating characteristic (ROC) curve. The levels of inflammatory cytokines were detected using enzyme‐linked immunosorbent assay. microRNA (miR)‐29b‐3p expression and pregnancy‐associated plasma protein A (PAPPA) level were detected. MIAT expression in CAD patients (4.23 [1.22–6.50]) was higher than that in non‐CAD controls (1.64 [0.05–2.93]) (p
Databáze: Directory of Open Access Journals
Externí odkaz: