Eczema control and treatment satisfaction in atopic dermatitis patients treated with dupilumab – a cross-sectional study from the BioDay registry
| Autor: | Jart A. F. Oosterhaven, Lotte S. Spekhorst, Junfen Zhang, Angelique N. Voorberg, Geertruida L. E. Romeijn, Celeste M. Boesjes, Marlies de Graaf, Marjolein S. de Bruin-Weller, Marie L. A. Schuttelaar |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Journal of Dermatological Treatment, Vol 33, Iss 4, Pp 1986-1989 (2022) |
| Druh dokumentu: | article |
| ISSN: | 0954-6634 1471-1753 09546634 |
| DOI: | 10.1080/09546634.2021.1937485 |
| Popis: | Background Eczema control is a new construct to be measured in atopic dermatitis (AD). Objectives Measuring patient-perceived eczema control and treatment satisfaction in AD patients, treated with dupilumab between 16 and 52 weeks. Methods Cross-sectional questionnaire study. Patients from the Dutch BioDay registry completed the Atopic Dermatitis Control Test (ADCT), Recap of Atopic Eczema (RECAP) and Treatment Satisfaction Questionnaire for Medication, Version II (TSQM v. II), along with other Patient Reported Outcome Measures (PROMs). Results 104/157 patients responded (response rate 66.2%). Median ADCT score was 4 (interquartile range [IQR] 5); median RECAP score was 5 (IQR 6); median TSQM v.II global satisfaction score was 83.3 (IQR 25.0). According to the ADCT, 38.5–66.3% perceived their AD was ‘in control’, depending on the interpretability method used. Minimally clinically important difference (MCID) of ≥4 points for the DLQI and POEM was achieved respectively in N = 66 (84.6%) and N = 63 (78.8%) patients. Conclusion When considering the favorable scores on other PROMs and the TSQM v. II, and comparing these to the relatively low percentage of patients perceiving control according to the ADCT, interpretability of eczema control still appears difficult. Treatment satisfaction in the studied cohort was high. |
| Databáze: | Directory of Open Access Journals |
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