Cancer co-opts differentiation of B-cell precursors into macrophage-like cells

Autor: Chen Chen, Bongsoo Park, Emeline Ragonnaud, Monica Bodogai, Xin Wang, Le Zong, Jung-Min Lee, Isabel Beerman, Arya Biragyn
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-33117-y
Popis: The tumour microenvironment has been shown to change the phenotypes and functionality of immune cells to enable tumour propagation. Here authors show that cancers can derail B cell development to give rise to macrophage-like cells, contributing to cancer progression and metastasis via disabling local T cell response.
Databáze: Directory of Open Access Journals