Anticancer Alkaloid Lamellarins Inhibit Protein Kinases
| Autor: | Laurent Meijer, Masatomo Iwao, Fumito Ishibashi, Somsak Rucirawat, Poonsakdi Ploypradith, Olivier Lozach, Yoan Ferandin, Nolwenn Trinkler, Dianne Baunbæk |
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| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: | |
| Zdroj: | Marine Drugs, Vol 6, Iss 4, Pp 514-527 (2008) |
| Druh dokumentu: | article |
| ISSN: | 20080026 1660-3397 |
| DOI: | 10.3390/md20080026 |
| Popis: | Lamellarins, a family of hexacyclic pyrrole alkaloids originally isolated from marine invertebrates, display promising anti-tumor activity. They induce apoptotic cell death through multi-target mechanisms, including inhibition of topoisomerase I, interaction with DNA and direct effects on mitochondria. We here report that lamellarins inhibit several protein kinases relevant to cancer such as cyclin-dependent kinases, dualspecificity tyrosine phosphorylation activated kinase 1A, casein kinase 1, glycogen synthase kinase-3 and PIM-1. A good correlation is observed between the effects of lamellarins on protein kinases and their action on cell death, suggesting that inhibition of specific kinases may contribute to the cytotoxicity of lamellarins. Structure/activity relationship suggests several paths for the optimization of lamellarins as kinase inhibitors. |
| Databáze: | Directory of Open Access Journals |
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