Evaluating the Antibacterial Profile of Copper Oxide Nanoparticles – Vitamin E (CuO NPs-Vit E) Complex against Multidrug-resistant Escherichia coli and Staphylococcus aureus
| Autor: | Haris Variyathody, Malarvizhi Arthanari, Manohar Murugan, Gobianand Kuppannan |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Journal of Pure and Applied Microbiology, Vol 17, Iss 4, Pp 2080-2097 (2023) |
| Druh dokumentu: | article |
| ISSN: | 0973-7510 2581-690X |
| DOI: | 10.22207/JPAM.17.4.01 |
| Popis: | Millions of people die every year as a result of infections’ multidrug resistance (MDR) pathogens. Therefore, the creation of novel antibiotics is urgently required for the treatment of bacterial illnesses that are resistant to a variety of drugs. The current study concentrated on the development of copper oxide nanoparticles conjugated with Vitamin-E (CuO NPs-Vit E complex), which was evaluated using various approaches like FTIR (Fourier transform infrared spectroscopy), UV-Vis (ultraviolet-visible spectroscopy), SEM (scanning electron microscopy), XRD (X-ray diffraction). The antibacterial and anti-biofilm activity was investigated against MDR Escherichia coli and Staphylococcus aureus. The antioxidant properties of CuO NPs-Vit E complex were determined using DPPH and FRAP assay. The CuO NPs-Vit E complex showed excellent anti-bacterial, anti-biofilm, and antioxidant activities. Moreover, it was found to be biocompatible and non-toxic to normal cells. Therefore, the synthesized CuO NPs-Vit E complex can be used for the creation of new drugs for the treatment of multidrug-resistant bacterial infections. |
| Databáze: | Directory of Open Access Journals |
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