Dual-targeting strategy using trastuzumab and lapatinib in a patient with HER2 gene amplification in recurrent metachronous metastatic gallbladder carcinoma
| Autor: | Minfeng Ye, Jieqing Lv, Guangen Xu, Wei Wang, Yuanming Jing, Aijing Sun, Zengxin Lu, Xue Wu, Yichuan Liu, Yang W. Shao, Fang Liu, Feng Tao |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Journal of International Medical Research, Vol 47 (2019) |
| Druh dokumentu: | article |
| ISSN: | 0300-0605 1473-2300 03000605 |
| DOI: | 10.1177/0300060519847796 |
| Popis: | Gallbladder carcinoma (GBC) is a rare and highly aggressive tumor. Early diagnosis is challenging, which results in a poor prognosis using systemic therapy. Recent studies have identified a subset of GBC patients with HER2 gene (ERBB2) amplification that could benefit from HER2-targeted therapy. Here, we report one patient with recurrent metachronous GBC with metastasis, who received the combination of trastuzumab and lapatinib. This approach achieved a partial response for both the brain and the lung metastases. This study demonstrated that HER2 inhibition is a promising therapeutic strategy for GBC with HER2 amplification and, combined with lapatinib, it can effectively target brain metastasis. |
| Databáze: | Directory of Open Access Journals |
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