| Autor: |
A. N. Vasilev, P. G. Deryabin, G. A. Galegov |
| Jazyk: |
ruština |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Антибиотики и Химиотерапия, Vol 56, Iss 9-10, Pp 27-32 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
0235-2990 |
| Popis: |
In vitro activity of interferon-α-2b in combination with various antioxidants against the influenza virus and Herpes simplex was studied. The standard strains and a clinical strain of Herpes simplex isolated from a patient with resistance to acyclovir were used. The in vitro studie showed that antioxidants, such as alpho-tocoferol acetate (vitamin E), Unithiol and ascorbic acid had a significant antiinfluenzae and antiherpetic action on the influenza virus A/H5N1 and Herpes simplex variants. They protected up to 100% of the cell monolayer from the virus cytopathic effect. The taurin solutions had no antiviral activity irrespective of the infection dose. Combinations of interferon-α-2b with alpha-tocopherol acetate (vitamin E), Unithiol or ascorbic acid showed a significant synergistic effect: the antiviral activity of interferon increased several times. The antiinfluenza activity of interferon-a-2b in the presence of various concentrations of taurin did not change. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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