A randomized, double‐blind, vehicle‐controlled clinical study of hair regeneration using adipose‐derived stem cell constituent extract in androgenetic alopecia

Autor: Young Jin Tak, Sang Yeoup Lee, A Ra Cho, Young Sil Kim
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Stem Cells Translational Medicine, Vol 9, Iss 8, Pp 839-849 (2020)
Druh dokumentu: article
ISSN: 2157-6580
2157-6564
DOI: 10.1002/sctm.19-0410
Popis: Abstract Accumulating evidence suggests that adipose‐derived stem cell constituent extract (ADSC‐CE) helps hair regrowth in patients with androgenetic alopecia (AGA). However, the effects of ADSC‐CE have not been demonstrated in a randomized, double‐blind, vehicle‐controlled clinical trial. In this randomized, double‐blind, vehicle‐controlled clinical trial, 38 patients (29 men) with AGA were assigned to an intervention group (IG), with twice‐daily self‐application of the ADSC‐CE topical solution over the scalp with fingers, or to a control group (CG). Changes in hair count and thickness at 16 weeks from the baseline were evaluated using a phototrichogram. Overall, 34 (89%) patients (mean age, 45.3 years) completed the study. The phototrichogram at week 8 showed more increase in hair count in the IG than in the CG, and intergroup differences in the change of hair count remained significant until week 16 with overall changes of 28.1% vs 7.1%, respectively. Similarly, a significant improvement in hair diameter was observed in the IG (14.2%) after 16 weeks when compared with hair diameter in the CG (6.3%). Our findings suggest that the application of the ADSC‐CE topical solution has enormous potential as an alternative therapeutic strategy for hair regrowth in patients with AGA, by increasing both hair density and thickness while maintaining adequate treatment safety.
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