| Autor: |
Maria E. Monberg, Heather Geiger, Jaewon J. Lee, Roshan Sharma, Alexander Semaan, Vincent Bernard, Justin Wong, Fang Wang, Shaoheng Liang, Daniel B. Swartzlander, Bret M. Stephens, Matthew H. G. Katz, Ken Chen, Nicolas Robine, Paola A. Guerrero, Anirban Maitra |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-022-31376-3 |
| Popis: |
It is unclear if the molecular profiles of pancreatic ductal adenocarcinoma (PDAC) preclinical models remain stable during propagation. Here, the authors characterise clonal evolution throughout propagation in PDAC cell lines and a patient-derived organoid using single-cell genomics, transcriptomics and epigenomics. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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