Cysteamine ophthalmic hydrogel for the treatment of ocular cystinosis
| Autor: | Anxo Fernández-Ferreiro, Andrea Luaces-Rodríguez, Victoria Díaz-Tomé, María Gil-Martínez, María Teresa Rodríguez Ares, Rosario Touriño Peralba, José Blanco-Méndez, Miguel González-Barcia, Francisco Javier Otero-Espinar, María Jesús Lamas |
|---|---|
| Jazyk: | English<br />Spanish; Castilian |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Farmacia Hospitalaria, Vol 41, Iss 6, Pp 678-687 (2017) |
| Druh dokumentu: | article |
| ISSN: | 1130-6343 2171-8695 |
| DOI: | 10.7399/fh.10834 |
| Popis: | Ocular cystinosis is a rare disease characterised by the deposit of cystine crystals on the corneal surface, which hinder patients’ eyesight. Oral cysteamine is given as cysteamine; however, it does not reach the cornea due to the lack of corneal vascularization making necessary its administration by the topical ocular route. The aim of the present study is to determine the stability of an ophthalmic hydrogel of cysteamine, which can be potentially prepared at hospital pharmacy departments, under different preservation conditions during a follow-up of 30 days. Different physical and chemical parameters were evaluated: osmolality, pH and cysteamine concentration, which has been measured by a method of ultra performance liquid chromatography-tandem mass spectrometer (UPLC-MS/MS). Descriptive assays were also performed, such as transparency measurement and microbiological assays in order to verify its sterility. The obtained results allow us to conclude that the cysteamine hydrogel is stable during 30 days, being recommendable its preservation in refrigerated conditions. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|