Clinically Meaningful Responses to Sequential Gemcitabine-Based Chemotherapy Regimens in a Patient with Metastatic Pancreatic Cancer
| Autor: | Eiko Klimant, Maurie Markman, Daniela M. Albu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Naturopathic regimens
pancreatic cancer Pancreatic cancer response to chemotherapy Best responders to gemcitabine pancreatic cancer Pharmacogenomics of gemcitabine pancreatic adenocarcinoma Second- and third-line gemcitabine-based chemotherapy pancreatic carcinoma Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
| Zdroj: | Case Reports in Oncology, Vol 6, Iss 1, Pp 72-77 (2013) |
| Druh dokumentu: | article |
| ISSN: | 1662-6575 |
| DOI: | 10.1159/000346836 |
| Popis: | Pancreatic cancer exhibits profound chemoresistance resulting either from pre-existing (intrinsic) mechanisms, or from anticancer drug treatment itself (acquired chemoresistance). We present the case of a patient with pancreatic adenocarcinoma metastatic to the liver who experienced clinical, radiographic and tumor marker response to three lines of gemcitabine-based chemotherapy. The regimens included: 8 cycles of gemcitabine and oxaliplatin (GEMOX), 8 cycles of gemcitabine, docetaxel and capecitabine (GTX) and more than 3 cycles of gemcitabine and nab-paclitaxel, with an exceptional response 2 years from the initiation of chemotherapy for metastatic pancreatic cancer. |
| Databáze: | Directory of Open Access Journals |
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