Incidence and risk factors of severe acute high-altitude illness in healthy adults first entering the northern Tibetan Plateau of over 5,000 m

Autor: Chun Gao, Guo-Dong Qi, Dan Wang, Zhao-Hui Zhang, Zhong-Xing Liu, Rui-Dong Ge, Zong Yong, Li-E Yan
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Frontiers in Public Health, Vol 12 (2024)
Druh dokumentu: article
ISSN: 2296-2565
DOI: 10.3389/fpubh.2024.1400236
Popis: BackgroundOur study was designed to determine the incidence and risk factors of severe acute high-altitude illness (AHAI) in healthy adults first entering the northern Tibetan Plateau of over 5,000 m.MethodsIn our prospective observational study, we enrolled 500 people who were scheduled for fast ascension to the northern Tibetan Plateau. The primary outcome variable was severe AHAI, defined as the presence of serious symptoms that could not be ameliorated by general treatment and required evacuation to lower altitudes. According to the inclusion and exclusion criteria, a cohort of 383 healthy people was included in the statistical analysis. We calculated the incidence of severe AHAI, identified the risk factors, and the differences in the most severe symptoms experienced.ResultsSixty-eight people were diagnosed with severe AHAI, and the incidence was 17.8%. Compared to individuals without severe AHAI, those with severe AHAI were more likely to be over the age of 40 years, of Han Chinese nationality, and living at an altitude of
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