| Autor: |
Majd Al Assaad, Nara Shin, Michael Sigouros, Jyothi Manohar, Zoia Antysheva, Nikita Kotlov, Daria Kiriy, Anastasiia Nikitina, Mikhail Kleimenov, Anastasiya Tsareva, Anastasiya Makarova, Victoria Fomchenkova, Julia Dubinina, Alexandra Boyko, Nava Almog, David Wilkes, Joanna G. Escalon, Ashish Saxena, Olivier Elemento, Cora N. Sternberg, David M. Nanus, Juan Miguel Mosquera |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Frontiers in Oncology, Vol 13 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2234-943X |
| DOI: |
10.3389/fonc.2023.1274163 |
| Popis: |
Cancer of unknown primary (CUP) represents a significant diagnostic and therapeutic challenge, being the third to fourth leading cause of cancer death, despite advances in diagnostic tools. This article presents a successful approach using a novel genomic analysis in the evaluation and treatment of a CUP patient, leveraging whole-exome sequencing (WES) and RNA sequencing (RNA-seq). The patient, with a history of multiple primary tumors including urothelial cancer, exhibited a history of rapid progression on empirical chemotherapy. The application of our approach identified a molecular target, characterized the tumor expression profile and the tumor microenvironment, and analyzed the origin of the tumor, leading to a tailored treatment. This resulted in a substantial radiological response across all metastatic sites and the predicted primary site of the tumor. We argue that a comprehensive genomic and molecular profiling approach, like the BostonGene© Tumor Portrait, can provide a more definitive, personalized treatment strategy, overcoming the limitations of current predictive assays. This approach offers a potential solution to an unmet clinical need for a standardized approach in identifying the tumor origin for the effective management of CUP. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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