Paternal Expressed Gene 10 (PEG10) is decreased in early-onset preeclampsia

Autor:	Lydia Baird, Ping Cannon, Manju Kandel, Tuong-Vi Nguyen, Anna Nguyen, Georgia Wong, Cíara Murphy, Fiona C. Brownfoot, Elif Kadife, Natalie J. Hannan, Stephen Tong, Lucy A. Bartho, Tu’uhevaha J. Kaitu’u-Lino
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Placenta PEG10 Hypoxia Inflammation Preeclampsia TGF Gynecology and obstetrics RG1-991 Reproduction QH471-489
Zdroj:	Reproductive Biology and Endocrinology, Vol 21, Iss 1, Pp 1-13 (2023)
Druh dokumentu:	article
ISSN:	1477-7827
DOI:	10.1186/s12958-023-01116-3
Popis:	Abstract Background Preeclampsia is a severe complication of pregnancy which is attributed to placental dysfunction. The retrotransposon, Paternal Expressed Gene 10 (PEG10) harbours critical placental functions pertaining to placental trophoblast cells. Limited evidence exists on whether PEG10 is involved in preeclampsia pathogenesis. This study characterised the expression and regulation of PEG10 in placentas from patients with early-onset preeclampsia compared to gestation-matched controls. Methods PEG10 expression was measured in plasma and placentas collected from patients with early-onset preeclampsia (
Databáze:	Directory of Open Access Journals
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