Invasive pneumococcal disease in children under 60 months before and after availability of 13-valent conjugate vaccine

Autor: Johanna Martínez-Osorio, Juan José García-García, Fernando Moraga-Llop, Alvaro Díaz, Sergi Hernández, Anna Solé-Ribalta, Sebastià González-Peris, Conchita Izquierdo, Cristina Esteva, Gemma Codina, Ana María Planes, Sonia Uriona, Magda Campins, Pilar Ciruela, Luis Salleras, Ángela Domínguez, Carmen Muñoz-Almagro, Mariona F. de Sevilla
Jazyk: Spanish; Castilian
Rok vydání: 2022
Předmět:
Zdroj: Anales de Pediatría (English Edition), Vol 96, Iss 6, Pp 501-510 (2022)
Druh dokumentu: article
ISSN: 2341-2879
DOI: 10.1016/j.anpede.2021.06.005
Popis: Background: Invasive pneumococcal disease (IPD) is the most important bacterial infection in young children, and the introduction of pneumococcal conjugate vaccines has changed its presentation. This study compared the incidence, characteristics and serotype distribution of IPD before and after the introduction of the pneumococcal conjugate vaccine (PCV13). Methods: Prospective enrolment of patients with IPD aged less than 60 months and admitted to either of 2 tertiary care hospitals between January 2007 and December 2009 (pre-PCV13 period) and January 2012 and June-2016 (PCV13 period). Results: We identified 493 cases, 319 in the pre-PCV13 period and 174 in the PCV13 period. The incidence of IPD decreased from 89.7 to 34.4 casos per 100 000 habitantes ( −62%; P
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