| Autor: |
Raffi Francois, Houdebine Marietherese, Guillaumin Guyonne, Gordeeff Claire, Durand-Perdriel Marie-Henriette, Bourrut-Lacouture Martine, Muller Jean-Yves, Naudin Frederique, Germaud Patrick, Chailleux Edmond, Audrain Marie, Nael Virginie, Brunet-Courtois Benedicte, Tripodi Dominique, Boutoille David, Biron Charlotte, Potel Gilles, Roedlich Claude, Geraut Christian, Schablon Anja, Nienhaus Albert |
| Jazyk: |
angličtina |
| Rok vydání: |
2009 |
| Předmět: |
|
| Zdroj: |
Journal of Occupational Medicine and Toxicology, Vol 4, Iss 1, p 30 (2009) |
| Druh dokumentu: |
article |
| ISSN: |
1745-6673 |
| DOI: |
10.1186/1745-6673-4-30 |
| Popis: |
Abstract Introduction Using French cut-offs for the Tuberculin Skin Test (TST), results of the TST were compared with the results of an Interferon-γ Release Assay (IGRA) in Healthcare Workers (HCW) after contact to AFB-positive TB patients. Methods Between May 2006 and May 2007, a total of 148 HCWs of the University Hospital in Nantes, France were tested simultaneously with IGRA und TST. A TST was considered to indicate recent latent TB infection (LTBI) if an increase of >10 mm or if TST ≥ 15 mm for those with no previous TST result was observed. For those with a positive TST, chest X-ray was performed and preventive chemotherapy was offered. Results All HCWs were BCG-vaccinated. The IGRA was positive in 18.9% and TST ≥ 10 mm was observed in 65.5%. A recent LTBI was believed to be highly probable in 30.4% following TST. Agreement between IGRA and TST was low (kappa 0.041). In 10 (16.7%) out of 60 HCWs who needed chest X-ray following TST the IGRA was positive. In 9 (20%) out of 45 HCWs to whom preventive chemotherapy was offered following TST the IGRA was positive. Of those considered TST-negative following the French guidelines, 20.5% were IGRA-positive. In a two-step strategy - positive TST verified by IGRA - 18 out of 28 (64.3%) IGRA-positive HCWs would not have been detected using French guidelines for TST interpretation. Conclusion The introduction of IGRA in contact tracings of BCG-vaccinated HCWs reduces X-rays and preventive chemotherapies. Increasing the cut-off for a positive TST does not seem to be helpful to overcome the effect of BCG vaccination on TST. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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