Tranexamic acid reduces intraoperative red blood cell transfusion rates in craniosynostosis surgery: a 6-year retrospective analysis
| Autor: | Rositsa Tanova, Petra Vasileva, Dimo Yankov, Dilyan Ferdinandov, Simeon Georgiev, Nikolay Lilyanov |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Biotechnology & Biotechnological Equipment, Vol 38, Iss 1 (2024) |
| Druh dokumentu: | article |
| ISSN: | 13102818 1314-3530 1310-2818 |
| DOI: | 10.1080/13102818.2024.2338424 |
| Popis: | AbstractSurgery for craniosynostosis in children is associated with substantial intraoperative bleeding and the need for blood transfusions. Recent studies have supported the efficacy of tranexamic acid (TXA) in reducing blood loss and transfusion requirements. The records of 72 patients under 18 months of age who had undergone 113 surgeries for non-syndromic craniosynostosis in a single institution for 6 years were retrospectively analyzed. The transfusion requirements in infants with and without TXA administration were compared. The concept of patient blood management before and after TXA implementation in practice was also examined. The rate of intraoperative packed red blood cells (PRBC) transfusion was significantly lower in the TXA than in the non-TXA group (26.7% vs. 83%, p |
| Databáze: | Directory of Open Access Journals |
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