Assessment of Cardiovascular Disease in Autosomal Dominant Polycystic Kidney Disease
| Autor: | Antonietta Gigante, Adolfo Marco Perrotta, Francesca Tinti, Eleonora Assanto, Maurizio Muscaritoli, Silvia Lai, Rosario Cianci |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: |
autosomal dominant polycystic kidney disease
left ventricular hypertrophy heart rate variability cardiovascular risk flow-mediated dilation carotid intima–media thickness Technology Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 |
| Zdroj: | Applied Sciences, Vol 13, Iss 12, p 7175 (2023) |
| Druh dokumentu: | article |
| ISSN: | 2076-3417 |
| DOI: | 10.3390/app13127175 |
| Popis: | Autosomal dominant polycystic kidney disease (ADPKD) is an inherited kidney disease which leads to progressive kidney failure. About 5–10% of patients requiring renal replacement therapy are affected by ADPKD. Cardiovascular diseases are the main causes of morbidity and mortality in these patients with ADPKD; arterial hypertension (AH) is the first symptom with a very early onset. Anyway, some other cardiovascular abnormalities have been reported in ADPKD regardless of the presence of AH. With this background, we conducted a systematic review, collecting all randomized controlled trials (RCTs) and quasi-RCTs found on the main databases; we evaluated the evidence about different imaging techniques to grade the cardiovascular risk in a very early stage of disease. This review aims to describe all cardiovascular assessments in ADPKD patients to improve clinicians’ ability to discover cardiovascular involvement early, allowing appropriate therapies promptly. |
| Databáze: | Directory of Open Access Journals |
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