| Autor: |
Yingxue Ren, Daniel L. Vera, Kimberly A. Hughes, Jonathan H. Dennis |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
|
| Zdroj: |
Genomics Data, Vol 3, Iss C, Pp 146-147 (2015) |
| Druh dokumentu: |
article |
| ISSN: |
2213-5960 |
| DOI: |
10.1016/j.gdata.2015.01.001 |
| Popis: |
In eukaryotes, nucleosomes participate in all DNA-templated events by regulating access to the underlying DNA sequence. However, nucleosome dynamics during a genome response have not been well characterized [1,2]. We stimulated Drosophila S2 cells with heat-killed Gram-negative bacteria Salmonella typhimurium, and mapped genome-wide nucleosome occupancy at high temporal resolution by MNase-seq using Illumina HiSeq 2500. We show widespread nucleosome occupancy change in S2 cells during the immune response, with the significant nucleosomal loss occurring at 4 h after stimulation. Data have been deposited to the Gene Expression Omnibus (GEO) database repository with the dataset identifier GSE64507. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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