Syphilitic meningitis in HIV-patients with meningeal syndrome: report of two cases and review

Autor: Ricardo Andrade Carmo, Alexandre Sampaio Moura, Paulo Pereira Christo, Ana Cláudia Morandi, Marcelo Silva Oliveira
Jazyk: angličtina
Předmět:
Zdroj: Brazilian Journal of Infectious Diseases, Vol 5, Iss 5, Pp 280-287
Druh dokumentu: article
ISSN: 1678-4391
1413-8670
DOI: 10.1590/S1413-86702001000500007
Popis: Few patients with symptomatic neurosyphilis present with signs and symptoms of acute meningitis. Here we report two cases of syphilitic meningitis diagnosed in HIV patients with meningeal syndrome. The first case, a 30-year-old black bisexual male, had concurrent meningeal and ocular syphilis with persistent unusually low CSF glucose levels. He responded well to 21 days of intravenous penicillin therapy. The second case was a 55-year-old female with epilepsy, depression, behavioral disorder and confusion. The diagnosis of HIV infection was made after onset of the syphilitic meningitis. She was treated with 21 days i.v. penicillin with improvement in her clinical condition. The clinical aspects of combined neurosyphilis and HIV infection, plus special features of diagnosis and treatment are discussed.
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