Regeneration of Thyroid Glands in the Spleen Restores Homeostasis in Thyroidectomy Mice

Autor: Xue‐Jiao Tian, Zhi‐Jie Yin, Zhen‐Jiang Li, Zhen‐Zhen Wang, Zhen Xing, Chun‐Yan Liu, Lin‐Tao Wang, Chun‐Ming Wang, Jun‐Feng Zhang, Lei Dong
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Advanced Science, Vol 11, Iss 6, Pp n/a-n/a (2024)
Druh dokumentu: article
ISSN: 2198-3844
20230591
DOI: 10.1002/advs.202305913
Popis: Abstract Surgical removal of the thyroid gland (TG) for treating thyroid disorders leaves the patients on lifelong hormone replacement that partially compensates the physiological needs, but regenerating TG is challenging. Here, an approach is reported to regenerate TG within the spleen for fully restoring the thyroid's functions in mice, by transplanting thyroid tissue blocks to the spleen. Within 48 h, the transplanted tissue efficiently revascularizes, forming thyroid follicles similar to the native gland after 4 weeks. Structurally, the ectopically generated thyroid integrates with the surrounding splenic tissue while maintaining its integrity, separate from the lymphatic tissue. Functionally, it fully restores the native functions of the TG in hormone regulation in response to physiological stimuli, outperforming the established method of oral levothyroxine therapy in maintaining systemic homeostasis. The study demonstrates the full restoration of thyroid functions post‐thyroidectomy by intrasplenic TG regeneration, providing fresh insights for designing novel therapies for thyroid‐related disorders.
Databáze: Directory of Open Access Journals
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