| Autor: |
James H Park, Hester vanWyk, Donald C McMillan, Joanne Edwards, Clare Orange, Paul G Horgan, Campbell SD Roxburgh |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
The Journal of Pathology: Clinical Research, Vol 6, Iss 1, Pp 30-39 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2056-4538 |
| DOI: |
10.1002/cjp2.143 |
| Popis: |
Abstract The tumour microenvironment (TME) is recognised as an important prognostic characteristic and therapeutic target in patients with colorectal cancer (CRC). However, assessment generally utilises surgically resected specimens, precluding neoadjuvant targeting. The present study investigated the feasibility of intra‐epithelial CD3+ T‐lymphocyte density and tumour stroma percentage (TSP) assessment using preoperative colonoscopic biopsies from 115 patients who had undergone resection of stages I–III CRC, examining the relationship between biopsy and surgically resected specimen‐based assessment, and the relationship with cancer‐specific survival (CSS). High biopsy CD3+ density was associated with high CD3+ density in the invasive margin, cancer stroma and intra‐epithelial compartments of surgically resected specimens (area under the curve > 0.62, p 0.7 (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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