The Study of Nitric Oxide Synthase 3 (NOS3) T-786C and 4a4b Gene Polymorphism in Iranian Men with Varicocele
| Autor: | Seyede Nafise Tabatabaei, Mohammad Mehdi Heidari, Mehri Khatami |
|---|---|
| Jazyk: | perština |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, Vol 13, Iss 12, Pp 45-54 (2020) |
| Druh dokumentu: | article |
| ISSN: | 1735-7799 2008-1375 |
| Popis: | Background and Objectives: Varicocele is one of the most common causes of male infertility. Varicocele is an abnormal dilatation and tortuosity of veins of the pampiniform plexus, which drain the testis. Studies have shown that elevated level of oxidative stress markers, such as nitric oxide (NO) in the dilated veins of patients with varicocele impair testicular function. The aim of this study, was to investigate the relationship between nitric oxide synthase 3 (NOS3), T-786C, and 4a4b gene polymorphism as a common genetic factor with the risk of varicocele in Iranian men. Methods: The association of NOS3 T-786C and 4a4b gene polymorphisms in 60 Iranian men with varicocele and 61 control samples, were investigated using Multiplex-ARMS PCR and conventional PCR techniques. Data were statistically analyzed by t-test at the significance level of p |
| Databáze: | Directory of Open Access Journals |
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