| Autor: |
Yuxi Gao, Lijuan Gao, Endiao Zhu, Yunhong Yang, Mi Jie, Jiaqian Zhang, Zhiqiang Pan, Chengfeng Xia |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Nature Communications, Vol 14, Iss 1, Pp 1-9 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-023-43748-4 |
| Popis: |
Abstract Alkene dicarbofunctionalization is an efficient strategy and operation-economic fashion for introducing complexity in molecules. A nickel/photoredox dual catalyzed arylalkylation of nonactivated alkenes for the simultaneous construction of one C(sp 3)−C(sp 3) bond and one C(sp 3)−C(sp 2) bond has been developed. The mild catalytic method provided valuable indanethylamine derivatives with wide substrate scope and good functional group compatibility. An enantioselective dicarbofunctionalization was also achieved with pyridine-oxazoline as a ligand. The efficiency of metallaphotoredox dicarbofunctionalization was demonstrated for the concise synthesis of pharmaceutically active compounds. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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