Antimicrobial, antioxidant and antibiofilm activities of polysaccharides extracted from Moringa oleifera leaves
| Autor: | Lamis S. Mohamed, Mohamed E. El Awady, Zeinab M.H. Kheiralla, Soheir S. Maklad, Elham E. Moustafa |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Journal of Scientific Research in Science, Vol 40, Iss 2, Pp 72-83 (2023) |
| Druh dokumentu: | article |
| ISSN: | 2356-8364 2356-8372 |
| DOI: | 10.21608/JSRS.2023.331816 |
| Popis: | Moringa oleifera is one of the world's most significant therapeutic plants, it is rich in many phytochemicals including polysaccharides. Natural polysaccharides have a wide range of beneficial therapeutic and health-promoting properties. The current study investigated the antimicrobial in a 96-well plate, antioxidant by DPPH scavenging assay and antibiofilm activities of both polysaccharides (MOLPs) extracted from M. oleifera leaves and crude extracts of leaves (MOLCEs) by different solvents (methanol, 70% ethanol, ethyl acetate, and hot distilled water (80°C)). Results revealed that the antimicrobial activity of MOLPs against S. aureus, B. Subtilis, E. coli, and P. aeruginosa at 500g/ml was 72.7%, 73.1%, 75.2%, and 74.4%, respectively. The antimicrobial activity of hot water crude extract ranged from 67% to 71% while other crude extracts were less effective. DPPH scavenging activity of MOLPs and MOLCEs was concentration-dependent, at 500 g/ml it was 76.56% and 81.87% for MOLPs and hot aqueous crude extract, respectively. Other crude extracts were less effective. The biofilm inhibitory activity of MOLPs against S. aureus and E. coli was 62.56% and 65.65%, respectively while was 55.5% and 57.42% for hot water crude extract. Other MOLCEs by organic solvents (methanol, 70% ethanol and ethyl acetate) showed low inhibitory activity. These results confirmed the importance of polysaccharides as a bioactive agent that can be used as a promising therapeutic agent. |
| Databáze: | Directory of Open Access Journals |
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