| Autor: |
Innocent Mbulli Ali, Valery Pacome Kom Tchuenkam, Sandra Sob Tagomo, Hornela Mawamba, Marcel Nyuylam Moyeh, Emmanuel Nfor Nfor, Akindeh Mbuh Nji, Calvino Tah Fomboh, William Dorian Nana, Jean-Paul Chedjou Kengne, Peter Thelma Ngwa Niba, Germaine Ekobo Ekoyol, Dorothy Fosah Achu, Jude Daiga Bigoga, Wilfred Fon Mbacham |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Heliyon, Vol 8, Iss 11, Pp e11861- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2405-8440 |
| DOI: |
10.1016/j.heliyon.2022.e11861 |
| Popis: |
The emergence and spread of Plasmodium falciparum (P.f) drug resistance is still a major concern in Sub-Saharan Africa and warrants that its evolution be monitored continuously. The present study aimed at determining the distribution of key P.f drug resistance-mediating alleles in circulating malaria parasites in the West region of Cameroon. A cross sectional hospital-based study was conducted in Dschang and Ngounso in the West region of Cameroon. The Pfcrt, Pfmdr1, and the Pfdhps genes were amplified through nested PCR in 208 malaria-infected samples of the 301 febrile outpatients enrolled. The presence or absence of mutations in the K76T, N86Y, A437G and A581G codons of these P.f. genes respectively were determined through restriction digestion analysis. The proportion of different alleles were estimated as percentages and compared between two study sites using the Chi square test. A p value |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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