The study of pharmacodynamics of a medicine based on humanized monoclonal antibodies against IL-17 in rabbit model of antigen-induced arthritis

Autor:	A. A. Nedorubov, A. V. Grachev, M. A. Varavko, E. L. Morozova
Jazyk:	ruština
Rok vydání:	2018
Předmět:	ревматоидный артрит моноклональные антитела интерлейкина-17 (il-17a) crp tnf-α rheumatoid arthritis monoclonal antibodies interleukin-17 (il-17a) Biotechnology TP248.13-248.65 Medicine
Zdroj:	Биопрепараты: Профилактика, диагностика, лечение, Vol 16, Iss 2, Pp 101-107 (2018)
Druh dokumentu:	article
ISSN:	2221-996X 2619-1156
Popis:	The present article contains scientific data on the assessment of specific activity of therapeutic humanized monoclonal antibodies against IL-17 in rabbit model of antigen-induced arthritis. Pharmacokinetics and immunogenicity of anti-IL-17A preparation have been studied. The severity of rheumatoid arthritis progression has been assessed by the levels of joint damage, the levels of inflammatory markers and according to Menkin histological grade.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/ce130e6cd7184eb0bfe7592322665683 Zobrazit plný text záznamu View record in DOAJ