Immune markers, diurnal blood pressure profile and cardiac function in virologically suppressed HIV-infected patients

Autor:	Ingjerd W. Manner, Bård Waldum-Grevbo, Birgit Nomeland Witczak, Morten Bækken, Olav Øktedalen, Ingrid Os, Thomas Schwartz, Ivar Sjaastad
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	hiv infection cd4/cd8 ratio nadir cd4 lymphocyte count non-dipping blood pressure pattern echocardiography diastolic dysfunction Diseases of the circulatory (Cardiovascular) system RC666-701
Zdroj:	Blood Pressure, Vol 26, Iss 6, Pp 332-340 (2017)
Druh dokumentu:	article
ISSN:	0803-7051 1651-1999 08037051
DOI:	10.1080/08037051.2017.1346459
Popis:	Purpose: Non-dipping nocturnal blood pressure (BP) pattern has been reported prevalent among HIV-infected patients and is associated with adverse cardiovascular outcomes. The aims of this observational study were to identify predictors of nocturnal BP decline, and to explore whether diurnal BP profile is associated with alterations in cardiac structure and function. Materials and methods: A total of 108 treated HIV-infected patients with suppressed viremia underwent ambulatory BP measurement, 51 of these patients also underwent echocardiography. Results: Non-dipping nocturnal BP pattern was present in 51% of the patients. Decreased nocturnal decline in systolic BP (SBP) correlated with lower CD4 count (rsp = 0.21, p = 0.032) and lower CD4/CD8 ratio (rsp = 0.26, p = 0.008). In multivariate linear regression analyses, lower BMI (p = 0.015) and CD4/CD8 ratio
Databáze:	Directory of Open Access Journals
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