| Autor: |
Jihang Chen, Hoi Shan Wong, Hoi Yan Leung, Pou Kuan Leong, Wing Man Chan, Kam Ming Ko |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
Journal of Functional Foods, Vol 9, Iss , Pp 211-224 (2014) |
| Druh dokumentu: |
article |
| ISSN: |
1756-4646 |
| DOI: |
10.1016/j.jff.2014.04.021 |
| Popis: |
It has previously been demonstrated that HCY2, an ursolic acid-enriched fraction derived from Cynomorii Herba, induced mitochondrial uncoupling in heart, liver and kidney tissues of rats. In the present study, we investigated whether HCY2 co-treatment can reduce the body weight in high fat diet (HFD)-fed mice by virtue of mitochondrial uncoupling in skeletal muscle. The results showed that HCY2 co-treatment significantly reduced the body weight gain and white fat pads in HFD-fed mice. The weight reduction effect of HCY2 was associated with the induction of mitochondrial uncoupling in skeletal muscle, amelioration of HFD-induced hyperglycaemia and impairment in glucose tolerance as well as dyslipidaemia and fatty liver in HFD-fed mice. It is likely that HCY2 reduces body weight by increasing energy expenditure, presumably via mitochondrial uncoupling in skeletal muscle. HCY2 may therefore offer a promising prospect in preventing obesity and the associated metabolic syndrome and health consequences. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full Text from ScienceDirect