Prolonged and extended impacts of SARS-CoV-2 on the olfactory neurocircuit

Autor: Megumi Kishimoto-Urata, Shinji Urata, Ryoji Kagoya, Fumiaki Imamura, Shin Nagayama, Rachel A. Reyna, Junki Maruyama, Tatsuya Yamasoba, Kenji Kondo, Sanae Hasegawa-Ishii, Slobodan Paessler
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Druh dokumentu: article
ISSN: 2045-2322
DOI: 10.1038/s41598-022-09731-7
Popis: Abstract The impact of SARS-CoV-2 on the olfactory pathway was studied over several time points using Syrian golden hamsters. We found an incomplete recovery of the olfactory sensory neurons, prolonged activation of glial cells in the olfactory bulb, and a decrease in the density of dendritic spines within the hippocampus. These data may be useful for elucidating the mechanism underlying long-lasting olfactory dysfunction and cognitive impairment as a post-acute COVID-19 syndrome.
Databáze: Directory of Open Access Journals
Nepřihlášeným uživatelům se plný text nezobrazuje