| Autor: |
Junji Itou, Rei Takahashi, Hiroyuki Sasanuma, Masataka Tsuda, Suguru Morimoto, Yoshiaki Matsumoto, Tomoko Ishii, Fumiaki Sato, Shunichi Takeda, Masakazu Toi |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
iScience, Vol 23, Iss 2, Pp - (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2589-0042 |
| DOI: |
10.1016/j.isci.2020.100821 |
| Popis: |
Summary: Mammary ductal dysplasia is a phenotype observed in precancerous lesions and early-stage breast cancer. However, the mechanism of dysplasia formation remains elusive. Here we show, by establishing a novel dysplasia model system, that estrogen, a female hormone, has the potential to cause mammary ductal dysplasia. We injected estradiol (E2), the most active form of estrogen, daily into scid mice with a defect in non-homologous end joining repair and observed dysplasia formation with cell proliferation at day 30. The protooncogene Myc is a downstream target of estrogen signaling, and we found that its expression is augmented in mammary epithelial cells in this dysplasia model. Treatment with a Myc inhibitor reduced E2-induced dysplasia formation. Moreover, we found that isoflavones inhibited E2-induced dysplasia formation. Our dysplasia model system provides insights into the mechanistic understanding of breast tumorigenesis and the development of breast cancer prevention. : Molecular Biology; Cell Biology; Cancer Subject Areas: Molecular Biology, Cell Biology, Cancer |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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