MeCP2 SUMOylation rescues Mecp2-mutant-induced behavioural deficits in a mouse model of Rett syndrome

Autor: Derek J. C. Tai, Yen C. Liu, Wei L. Hsu, Yun L. Ma, Sin J. Cheng, Shau Y. Liu, Eminy H. Y. Lee
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Nature Communications, Vol 7, Iss 1, Pp 1-18 (2016)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/ncomms10552
Popis: Post-translational modifications of methyl-CpG-binding protein 2 (MeCP2) are important for its function and dysfunction in Rett syndrome. Here, Tai et al. show a functional interaction between MeCP2 SUMOylation and phosphorylation in rodent behavior and synaptic plasticity.
Databáze: Directory of Open Access Journals