Clinical outcomes of HeartMate 3 left ventricular assist device support with a Bridge to Transplant vs a Destination Therapy strategy: a single-centre retrospective cohort

Autor: John Kikoïne, Anna Nowacka, Sara Schukraft, Tamila Abdurashidova, Patrick Yerly, Piergiorgio Tozzi, Zied Ltaief, Lorenzo Rosner, Roger Hullin, Matthias Kirsch
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Swiss Medical Weekly, Vol 154, Iss 7 (2024)
Druh dokumentu: article
ISSN: 1424-3997
DOI: 10.57187/s.3529
Popis: INTRODUCTION: Real-world outcomes with the HeartMate 3 left ventricular assist device (LVAD) depending on whether it’s a bridge to transplantation (BTT) or destination therapy (DT) are poorly studied. We aimed to compare the profile and clinical outcomes of patients supported with HeartMate 3 according to a BTT or a DT pre-implantation strategy. METHODS: All patients consecutively implanted with HeartMate 3 at our centre (University Hospital of Lausanne, Switzerland) in 2015–2022 were analysed in a retrospective observational study. Indications for HeartMate 3 implantation were advanced heart failure despite optimal medical treatment. Patients were treated with a vitamin K antagonist anticoagulant combined with antiplatelet therapy after HeartMate 3 implantation and were followed up monthly at our institution. RESULTS: Among 71 patients implanted with HeartMate 3 between 2015 and 2022, 51 (71.8%) were implanted as a BTT and 20 (28.2%) as DT. Their median age was 58 (IQR: 52–69) years and 84% of patients were classified as INTERMACS profiles 2–4. The median follow-up duration was 18.3 (IQR: 7.5–33.9) months. Patients in the DT group were older than those in the BTT group (p
Databáze: Directory of Open Access Journals