| Autor: |
Vicente Sperb Antonello, Marcelo Campos Appel-da-Silva, Dimas Alexandre Kliemann, Breno Riegel Santos, Cristiane Valle Tovo |
| Jazyk: |
angličtina |
| Rok vydání: |
2013 |
| Předmět: |
|
| Zdroj: |
Brazilian Journal of Infectious Diseases, Vol 17, Iss 5, Pp 551-554 (2013) |
| Druh dokumentu: |
article |
| ISSN: |
1413-8670 |
| DOI: |
10.1016/j.bjid.2013.01.015 |
| Popis: |
Objective: To evaluate the influence of hepatitis C virus on immunological and virological responses after highly active antiretroviral therapy initiation in human immunodeficiency virus/hepatitis C virus coinfected patients compared to monoinfected human immunodeficiency virus-infected patients. Methods: The study enrolled 65 human immunodeficiency virus-1-infected subjects who initiated highly active antiretroviral therapy and attended follow-up visits over 48 weeks from 2008 to 2010. They were grouped based on hepatitis C virus-RNA results. Virological and immunological responses were monitored at baseline and at the end of weeks 12, 24, 36, and 48. Results: There were 35 human immunodeficiency virus monoinfected and 30 human immunodeficiency virus/hepatitis C virus coinfected patients. In the present study human immunodeficiency virus/hepatitis C virus coinfection did not seem to influence CD4 T-lymphocytes recovery. There was no difference between the curves of CD4 T-lymphocytes raise of coinfected and monoinfected groups. Conclusion: This prospective study confirms that hepatitis C virus infection does not seem to be associated with impaired CD4 T-lymphocytes recovery after HAART. Keywords: HIV, Hepatitis C, Coinfection, HAART, CD4, Immunological response |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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