Chemical Constituents from Ethanoic Extracts of the Aerial Parts of Leea aequata L., a Traditional Folk Medicine of Myanmar

Autor: Nay Lin Tun, Dong-Bao Hu, Meng-Yuan Xia, Dong-Dong Zhang, Jun Yang, Thaung Naing Oo, Yue-Hu Wang, Xue-Fei Yang
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Natural Products and Bioprospecting, Vol 9, Iss 3, Pp 243-249 (2019)
Druh dokumentu: article
ISSN: 2192-2195
2192-2209
DOI: 10.1007/s13659-019-0209-y
Popis: Abstract We aimed at reporting the chemical constituents and antimicrobial activities of Leea aequata L., a traditional folk medicine used in Myanmar for the treatment of wounds and skin diseases. A new neolignan, (7S,8R)-9′-O-acetylcedrusin (1), a new lactam, (3S,4S)-4-chloro-3-hydroxypiperidin-2-one (2), along with 21 known compounds, including five lignans (3–7), four flavonoid glycosides (8–11), and others (12–23), were isolated from the ethanoic extract of the aerial parts of L. aequata. The structures of the new compounds were determined by NMR, MS, and ECD spectra. For all the antimicrobial tests of the 23 compounds, only 3,4,5-trihydroxybenzoic acid ethyl ester (17) showed weak inhibitory activities against Escherichia coli and Salmonella enterica subsp. enterica. Graphical Abstract
Databáze: Directory of Open Access Journals
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