Lung Cancer Screening: Low-Dose Thoracic Computed Tomography Performed in a High-Risk Portuguese Population
| Autor: | Sara Moura Cabral, Inês Abreu, Daniela Madama, Amélia Estevão, Eugénio Cordeiro, João Pimentel, Nuno Miranda, António Jorge Ferreira, Carlos Robalo Cordeiro |
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| Jazyk: | English<br />Portuguese |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Acta Médica Portuguesa, Vol 36, Iss 9 (2023) |
| Druh dokumentu: | article |
| ISSN: | 0870-399X 1646-0758 |
| DOI: | 10.20344/amp.16847 |
| Popis: | Introduction: The Urgeiriça mines were once the main uranium producer in Portugal. The aim of this study was to estimate the benefit of low-dose chest computed tomography (LDCT) for lung cancer screening in former miners that were considered as being at high-risk. Methods: A subgroup of former miners of the Uranium National Company exposed to uranium and with a smoking load greater than 20 pack-years, agreed to perform a LDCT. The Fleischner Society Guidelines were used to classify the nodules and establish follow-up. Results: Initially, 265 former employees of the Uranium National Company were included. The mean time of employment was 15 (0 - 45) years. The non-smokers represented 50.9% and 30.2% were ever smokers; the remaining chose not to respond. One diagnosis of lung cancer was initially made. In the second phase, a subgroup of 66 former miner underwent a LDCT, 37 of whom presented pulmonary nodules. Most computed tomography (CT) scans revealed one single nodule (n = 13) and the mean size was 5 (1 - 16) mm. A suspicious 16 mm spiculated nodule was evaluated with PET/CT, and percutaneous and surgical biopsies, ultimately revealing a benign lesion. Conclusion: The data highlights the importance of lung cancer screening in high-risk populations. This was, to the best of our knowledge, the first study performed in Portugal and can act as a bridge towards a wider implementation in the country. |
| Databáze: | Directory of Open Access Journals |
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