Astragalus Polysaccharides and Metformin May Have Synergistic Effects on the Apoptosis and Ferroptosis of Lung Adenocarcinoma A549 Cells
| Autor: | I-Yun Lee, Ting-Chung Wang, Yu-Jen Kuo, Wei-Tai Shih, Pei-Rung Yang, Cheng-Ming Hsu, Yu-Shih Lin, Ren-Shyang Kuo, Ching-Yuan Wu |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Current Issues in Molecular Biology, Vol 46, Iss 8, Pp 7782-7794 (2024) |
| Druh dokumentu: | article |
| ISSN: | 1467-3045 1467-3037 85544159 |
| DOI: | 10.3390/cimb46080461 |
| Popis: | Astragalus polysaccharides (APSs), the compounds extracted from the common herb Astragalus membranaceus, have been extensively studied for their antitumor properties. In this study, we investigated the effect of APS on lung adenocarcinoma A549 cells. The effects of APS and the anti-diabetic drug metformin on apoptosis and ferroptosis were compared. Furthermore, the combination treatment of APS and metformin was also investigated. We found that APS not only reduced the growth of lung cancer cells but also had a synergistic effect with metformin on A549 cells. The study results showed that it may be promising to use APS and metformin as a combination therapy for the treatment of lung adenocarcinoma. |
| Databáze: | Directory of Open Access Journals |
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