The ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretion
| Autor: | Kazi Mirajul Hoque, Eryn E. Dixon, Raychel M. Lewis, Jordyn Allan, Gregory D. Gamble, Amanda J. Phipps-Green, Victoria L. Halperin Kuhns, Anne M. Horne, Lisa K. Stamp, Tony R. Merriman, Nicola Dalbeth, Owen M. Woodward |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020) |
| Druh dokumentu: | article |
| ISSN: | 2041-1723 63333244 |
| DOI: | 10.1038/s41467-020-16525-w |
| Popis: | The common ABCG2 variant Q141K contributes to hyperuricemia and gout risk. Here, using a human interventional study and a new orthologous mouse model, the authors report a tissue specific pathobiology of the Q141K variant, and support a significant role for ABCG2 in urate excretion in both the kidney and intestine. |
| Databáze: | Directory of Open Access Journals |
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