| Autor: |
Rodrigo Gonzalez Bonhin, Vanessa Brito Campoy Rocha, Guilherme Machado de Carvalho, Alexandre Caixeta Guimarães, Agrício Nubiato Crespo, Carlos Takahiro Chone, Eliane M.I. Amstalden |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
Brazilian Journal of Otorhinolaryngology, Vol 81, Iss 1, Pp 58-62 (2015) |
| Druh dokumentu: |
article |
| ISSN: |
1808-8686 |
| DOI: |
10.1016/j.bjorl.2014.08.016 |
| Popis: |
Introduction: Squamous cell carcinoma is the most common neoplasm of the larynx, and its evolution depends on tumor staging. Vascular endothelial growth factor is a marker of angiogenesis, and its expression may be related to increased tumor aggressiveness, as evidenced by the presence of cervical lymphatic metastases. Objectives: To evaluate the expression of the vascular endothelial growth factor marker in non-glottic advanced squamous cell carcinoma of the larynx (T3/T4) and correlate it with the presence of cervical lymph node metastases. Methods: Retrospective clinical study and immunohistochemical analysis of vascular endothelial growth factor through the German scale of immunoreactivity in products of non-glottic squamous cell carcinomas. Results: This study analyzed 15 cases of advanced non-glottic laryngeal tumors (T3/T4), four of which exhibited cervical lymphatic metastases. There was no correlation between vascular endothelial growth factor expression and the presence of cervical metastases. Conclusion: Although vascular endothelial growth factor was expressed in a few cases, there was no correlation with the spread of cervical lymph metastases. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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