Noncoding RNAs in Diabetic Nephropathy: Pathogenesis, Biomarkers, and Therapy

Autor: Jiarong Lv, Yu Wu, Yifeng Mai, Shizhong Bu
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Journal of Diabetes Research, Vol 2020 (2020)
Druh dokumentu: article
ISSN: 2314-6745
2314-6753
DOI: 10.1155/2020/3960857
Popis: The correlation between diabetes and systematic well-being on human life has long established. As a common complication of diabetes, the prevalence of diabetic nephropathy (DN) has been increasing globally. DN is known to be a major cause of end-stage kidney disease (ESKD). Till now, the molecular mechanisms for DN have not been fully explored and the effective therapies are still lacking. Noncoding RNAs are a class of RNAs produced by genome transcription that cannot be translated into proteins. It has been documented that ncRNAs participate in the pathogenesis of DN by regulating inflammation, apoptosis, autophagy, cell proliferation, and other pathological processes. In this review, the pathological roles and diagnostic and therapeutic potential of three types of ncRNAs (microRNA, long noncoding RNA, and circular RNA) in the progression of DN are summarized and illustrated.
Databáze: Directory of Open Access Journals
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