Multi-step screening of DNA/lipid nanoparticles and co-delivery with siRNA to enhance and prolong gene expression

Autor: Yining Zhu, Ruochen Shen, Ivan Vuong, Rebekah A. Reynolds, Melanie J. Shears, Zhi-Cheng Yao, Yizong Hu, Won June Cho, Jiayuan Kong, Sashank K. Reddy, Sean C. Murphy, Hai-Quan Mao
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-31993-y
Popis: Plasmid DNA offers extended transgene expression duration compared to mRNA technologies. Here, using a multi-step screening platform, the authors report the best performing nanoparticle formulations for liver-targeted plasmid DNA expression in vivo.
Databáze: Directory of Open Access Journals