Candida albicans meningitis in an infant with noonan syndrome

Autor: Faezeh Ahmadi, Maedeh Ahmadi, Bahareh Yaghmaei, Farideh Nejat, Nima Rezaei, Setareh Mamishi
Jazyk: angličtina
Předmět:
Zdroj: Brazilian Journal of Infectious Diseases, Vol 13, Iss 6, Pp 452-453
Druh dokumentu: article
ISSN: 1678-4391
1413-8670
DOI: 10.1590/S1413-86702009000600012
Popis: Noonan syndrome is a rare disorder, characterized by several malformations such as dysplasia and stenosis of the pulmonary valve, atrial septal defect and a typical pattern of hypertrophic cardiomyopathy. We describe here a 1-month old girl, who was referred to our center with seizure and apnea. She had wide anterior fontanel, head circumference and sunset eye. Intaventricular hemorrhage by sonography and atrial septal defect and hypertrophy cardiomyopathy by echocardiography were detected. Clinical and laboratory findings of the patient were compatible with a diagnosis of Noonan syndrome, which was also confirmed by molecular analysis. Candida albicans was grown in the blood and cerebrospinal fluid cultures. Treatment with Amphotrycine B was started for the patient and she responded well to this therapy. Early diagnosis and appropriate diagnosis of a rare condition in the patient with such rare disease are the main keys to avoid further complications and even death of patient.
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