Autor: |
Guillaume Martel, Tori Lenet, Christopher Wherrett, François-Martin Carrier, Leah Monette, Aklile Workneh, Karine Brousseau, Monique Ruel, Michaël Chassé, Yves Collin, Franck Vandenbroucke-Menu, Élodie Hamel-Perreault, Michel-Antoine Perreault, Jeieung Park, Shirley Lim, Véronique Maltais, Philemon Leung, Richard W. D. Gilbert, Maja Segedi, Jad Abou-Khalil, Kimberly A. Bertens, Fady K. Balaa, Tim Ramsay, Dean A. Fergusson |
Jazyk: |
angličtina |
Rok vydání: |
2023 |
Předmět: |
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Zdroj: |
Trials, Vol 24, Iss 1, Pp 1-13 (2023) |
Druh dokumentu: |
article |
ISSN: |
1745-6215 |
DOI: |
10.1186/s13063-022-07008-y |
Popis: |
Abstract Introduction Blood loss and red blood cell (RBC) transfusion in liver surgery are areas of concern for surgeons, anesthesiologists, and patients alike. While various methods are employed to reduce surgical blood loss, the evidence base surrounding each intervention is limited. Hypovolemic phlebotomy, the removal of whole blood from the patient without volume replacement during liver transection, has been strongly associated with decreased bleeding and RBC transfusion in observational studies. This trial aims to investigate whether hypovolemic phlebotomy is superior to usual care in reducing RBC transfusions in liver resection. Methods This study is a double-blind multicenter randomized controlled trial. Adult patients undergoing major hepatic resections for any indication will be randomly allocated in a 1:1 ratio to either hypovolemic phlebotomy and usual care or usual care alone. Exclusion criteria will be minor resections, preoperative hemoglobin |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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