| Autor: |
Rosemeire Arai Yoshida, Tiago Bertola Lobato, Renata Gorjão, Lucas Santiago França, Lívia Araujo Alves, Maria Teresa Botti Rodrigues Santos |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Frontiers in Dental Medicine, Vol 4 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2673-4915 |
| DOI: |
10.3389/fdmed.2023.1208243 |
| Popis: |
BackgroundElevated levels of inflammatory mediators in saliva have been described in individuals with cerebral palsy (CP).ObjectiveThe aim of this study was to detect and quantify the pathogens Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum and Prevotella intermedia in the saliva of adolescents with CP.MethodsThis is a cross-sectional study with adolescents with CP to detect periodontopathogens from saliva samples. Initially, saliva was collected from the CP (n = 34) and control groups (n = 31), followed by the gingival index (GI) for distribution of the groups of individuals with CP and control with gingivitis (bleeding on probing ≥ 10%) and without gingivitis. Bacterial DNA was extracted from saliva samples for detection of periodontopathogens by quantitative PCR (q-PCR). Data were analyzed by Mann–Whitney and Kruskal–Wallis tests, analysis of variance t-test (ANOVA) with Tukey–Kramer post-hoc tests (p 0.05). A significant contrast was observed for the pathogen P. intermedia when comparing the difference in the control group (p = 0.0396). No major differences were detected in the quantification of periodontopathogens evaluated between the control group and CP.ConclusionAdolescents with CP showed variability in the detection of DNA of periodontopathogens, especially a great variation in the detection of P gingivalis in saliva of CP with gingivitis. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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