Theranostic Imaging Surrogates for Targeted Alpha Therapy: Progress in Production, Purification, and Applications

Autor:	Bryce J. B. Nelson, John Wilson, Jan D. Andersson, Frank Wuest
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	targeted alpha therapy alpha particle therapy PET imaging SPECT imaging targeted radionuclide therapy theranostics Medicine Pharmacy and materia medica RS1-441
Zdroj:	Pharmaceuticals, Vol 16, Iss 11, p 1622 (2023)
Druh dokumentu:	article
ISSN:	1424-8247
DOI:	10.3390/ph16111622
Popis:	This article highlights recent developments of SPECT and PET diagnostic imaging surrogates for targeted alpha particle therapy (TAT) radiopharmaceuticals. It outlines the rationale for using imaging surrogates to improve diagnostic-scan accuracy and facilitate research, and the properties an imaging-surrogate candidate should possess. It evaluates the strengths and limitations of each potential imaging surrogate. Thirteen surrogates for TAT are explored: 133La, 132La, 134Ce/134La, and 226Ac for 225Ac TAT; 203Pb for 212Pb TAT; 131Ba for 223Ra and 224Ra TAT; 123I, 124I, 131I and 209At for 211At TAT; 134Ce/134La for 227Th TAT; and 155Tb and 152Tb for 149Tb TAT.
Databáze:	Directory of Open Access Journals
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