Carboplatin hypersensitivity in children with glial tumors: a report of two cases

Autor: Tugce Kazgan, Aysu ilhan, Cemile Durmaz, Begul Yagci-Kupeli
Jazyk: English<br />Turkish
Rok vydání: 2016
Předmět:
Zdroj: Çukurova Üniversitesi Tıp Fakültesi Dergisi, Vol 41, Iss 4, Pp 796-798 (2016)
Druh dokumentu: article
ISSN: 0250-5150
DOI: 10.17826/cutf.254541
Popis: Carboplatin, commonly used chemotherapeutic agent in treatment of pediatric cancers, can cause life-threatening hypersensitivty reactions. Carboplatin hypersensitivity is protocol-specific and associated with repeated doses and prolonged use of the drug. Vincristin and carboplatin combination is used efficiently in treatment of pediatric low-grade gliomas. However, hypersensitivity reactions are frequently observed during usage of this protocol. Desensitization strategies with variable success rates were reported. Failure of these strategies may lead to cessation of carboplatin Here, we report two cases with carboplatin hypersensitivity treated with epinephrine administration, in whom carboplatin was discontinued after hypersensitivity reaction. [Cukurova Med J 2016; 41(4.000): 796-798]
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