| Autor: |
Angélica Marta Lopes, Patrick Buosi, Bruna de Mattos Farina, Rafael Fernandes-Ferreira, Camila Ive Ferreira Oliveira-Brancati, Denise Poltronieri Martins, Danilo Grünig Humberto da Silva, Nayara Alves Chaves, Lucia Helena Neves Marques, Gerardo Maria de Araújo Filho, Dorotéia Rossi Silva Souza |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Brain Disorders, Vol 11, Iss , Pp 100099- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2666-4593 |
| DOI: |
10.1016/j.dscb.2023.100099 |
| Popis: |
The objective of the present study was to assess the levels of oxidative stress biomarkers (OSB) in patients with pharmacoresistant temporal lobe epilepsy and mesial temporal sclerosis (TLE-MTS) in order to investigate a possible role of oxidative stress (OS) in the pathophysiology of such disease. Ninety-eight participants were included and distributed in three groups: group 1 (G1) - 25 patients with pharmacoresistant TLE-MTS, without comorbid PD; Group 2 (G2) - 21 patients with pharmacoresistant TLE-MTS with PD; Group 3 (G3) - 52 healthy control subjects. Serum levels of catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), reduced glutathione plus oxidated glutathione (total GSH), glucose-6-phosphate dehydrogenase (G6PD), Trolox-equivalent antioxidant capacity (TEAC), and thiobarbituric acid reactive substances (TBARS) were analyzed through spectrometry. The significance level was set at P0.05). A family history of epilepsy was more frequent among G1 and G2 groups when compared to G3 (P = 0.0002). Compared to controls, G1 and G2 presented higher CAT (P0.05). The lower levels of GPx, G6PD, and total GSH, as well as the higher CAT and TBARS levels observed in pharmaco-resistant TLE-MTS patients can indicate an imbalance between oxidizing agent production and elimination, supporting the hypothesis of a possible role of OS in the pathogenesis of this condition. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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