Combination of Anti-Cancer Drugs with Molecular Chaperone Inhibitors

Autor:	Maxim Shevtsov, Gabriele Multhoff, Elena Mikhaylova, Atsushi Shibata, Irina Guzhova, Boris Margulis
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	heat shock protein inhibitors molecular chaperones hsp90 hsp70 hsp27 concurrent therapy cancer therapy Biology (General) QH301-705.5 Chemistry QD1-999
Zdroj:	International Journal of Molecular Sciences, Vol 20, Iss 21, p 5284 (2019)
Druh dokumentu:	article
ISSN:	1422-0067
DOI:	10.3390/ijms20215284
Popis:	Most molecular chaperones belonging to heat shock protein (HSP) families are known to protect cancer cells from pathologic, environmental and pharmacological stress factors and thereby can hamper anti-cancer therapies. In this review, we present data on inhibitors of the heat shock response (particularly mediated by the chaperones HSP90, HSP70, and HSP27) either as a single treatment or in combination with currently available anti-cancer therapeutic approaches. An overview of the current literature reveals that the co-administration of chaperone inhibitors and targeting drugs results in proteotoxic stress and violates the tumor cell physiology. An optimal drug combination should simultaneously target cytoprotective mechanisms and trigger the imbalance of the tumor cell physiology.
Databáze:	Directory of Open Access Journals
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